Not long ago, a randomized placebo-controlled trial published by Total Food Magazine evaluated the effects of
Aged garlic extract (AGE) on the inflammation and immune system in obese people.
It shows that old garlic can inhibit the inflammatory response of obese people and improve cardiovascular health.
Before the trial began, the researchers recruited a total of 51 obese volunteers and randomly assigned them.
During the 6-week intervention period, subjects received 3.6 grams of AGE or placebo per day.
Before and after the start of the trial, the investigator assessed the subjects' levels of lipids and inflammatory markers.
The test results showed that at the end of the study, subjects with AGE had significantly lower inflammatory cytokines
such as IL-6 and TNF-α compared to placebo. At the same time, there was also a significant difference in LDL concentrations
in the blood between the two groups of subjects. However, there was no significant difference in the percentage of NK cells between the two groups of subjects.
Although total cholesterol and non-high-density lipoprotein cholesterol were different, they were not statistically significant.
The researchers believe that the ability of AGE to regulate the distribution of immune cells and the ability to prevent the increase of serum concentrations of IL-6 and TNF is the key to its function.
Adipocytes are the major cell type in adipose tissue and secrete IL-6, leptin, and adiponectin. In obese people, there is an increase in the number and size of adipocytes,
which leads to the secretion of excess adipokines and the formation of a pro-inflammatory environment in adipose tissue.
The level of inflammatory mediators in the serum of obese people increased, and was positively correlated with body mass index and waist circumference.
Inflammation plays an important role in the development of many diseases.
The results of this study are good news for anyone seeking to reduce the risk of inflammation. In addition,
it offers a simple solution for those seeking a weight management program and a better overall health.